Download PDF by H. Maurice Goodman: Basic Medical Endocrinology, Third Edition

By H. Maurice Goodman

ISBN-10: 0122904214

ISBN-13: 9780122904219

Uncomplicated clinical Endocrinology, 3rd variation presents up to date insurance of quickly unfolding advances within the figuring out of hormones desirous about regulating so much points of physically capabilities. The dialogue specializes in molecular and mobile elements of hormone construction and motion firmly rooted within the context of integrative body structure. issues are approached from the point of view of a physiologist with 4 a long time of training experience.
This e-book is richly illustrated with either descriptive schematic diagrams and laboratory findings got in medical stories. all of the 13 in-depth chapters starts off with an 'Overview' of the subject and ends with a 'Suggested analyzing' list.
* unmarried authorship presents continuity and consistency among chapters
* Richly illustrated with over 2 hundred illustrations
* IThirteen in-depth chapters incorporating the newest insights gleaned from quickly increasing genetic experiences of people and rodents
* writer has taught topic for over forty years

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Extra resources for Basic Medical Endocrinology, Third Edition

Sample text

CHARACTERISTICS OF RECEPTORS Hormone receptors are proteins or glycoproteins that are able to function as follows: 1. They distinguish their hormone from other molecules that may have very similar structures. Mechanisms of Hormone Action 21 2. They bind to the hormone (sometimes called a ligand) even when its concentration is exceedingly low (10−8–10−12 M). 3. They undergo a conformational change when bound to the hormone. 4. They catalyze biochemical events or transmit changes in molecular conformation to adjacent molecules, producing a biochemical change.

Introduction site of cleavage by Phospholipase C 2 3 O = - - - = - - 4 - O-P-O 1 O O O-P-O OH O Inositol Triphosphate 6 5 = - Diacylglycerol - OH OH - R 2 -C-O-C R 1 -C-O-C O C - O-P-O H2 O Figure 17 Phosphatidylinositol bisphosphate. When cleaved by phospholipase C, inositol 1,4,5triphosphate and diacylglycerol are formed. R1 and R2 are long chain fatty acids. from adenosine triphosphate (ATP) to a hydroxyl group in serine or threonine residues in proteins are called protein kinases. Hydroxyl groups of tyrosine residues may also be phosphorylated in this way, and the enzymes that catalyze this phosphorylation are called tyrosine kinases.

With modern technology it is now possible to create chimeric receptors in which the hormone recognition component of the receptor for one hormone can be fused to the signal-transducing component of the receptor for another hormone. The biochemical changes set in motion by hormone binding to such chimeric receptors are characteristic of the transduction component, and not the bound hormone (Figure 11). Under some pathophysiological circumstances an aberrant antibody may react with a receptor and produce a disease state that is indistinguishable from the disease that results from overproduction of the hormone, again indicating that the nature of the response is a property of the receptor.

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Basic Medical Endocrinology, Third Edition by H. Maurice Goodman


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